Research background

A closer look
at the science.

Graduate research in pharmacology and toxicology, followed by scientific roles in production and flow cytometry research and development.

Environmental compounds and the ABCG2 transporter

Kevin’s graduate thesis examined the effects of polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) on the ABCG2 transporter, also known as the breast cancer resistance protein.

The thesis title is Polychlorinated Biphenyls (PCBs) and Polybrominated Diphenyl Ethers (PBDEs) are Inhibitors of the Breast Cancer Resistance Protein (ABCG2) Transporter.

Methods used in graduate research

The research record includes mammalian cell culture, flow cytometry, and gas chromatography with electron capture detection (GC/ECD). The original thesis identifies GC/ECD for analysis of PCB 47 in cell pellet and media samples.

Mammalian cell cultureFlow cytometryGC/ECD

From a thesis to a conference contribution

A related abstract and poster, “Polychlorinated Biphenyls and Polybrominated Diphenyl Ethers are Inhibitors of the Breast Cancer Resistance Protein,” appeared in The Toxicologist, S1, page 419, in March 2009. See the complete presentation record.

02 / Industry experience

Scientific work beyond graduate study.

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Thermo Fisher Scientific

Scientist II · Flow Cytometry R&D

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Life Technologies

Scientist I · Production

03 / Evidence in context

Reading beyond a study’s headline.

A related educational article introduces questions about study design, outcomes, uncertainty, and how research findings apply to a specific population.

Read the educational draft

Professional connections

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